Thank you for the reply, signature-view.
There are a few things that Multi-Instance can't do, like using the "Blend" mode between two or more objects to create a huge variety of different objects.
Example
CV4_2026_drs_26_MGic_01.c4d
One line from the documentation might stand out, while not replacing all other content: "Is it still worth using the Render Instance mode? Yes, this is still to be seen as a kind of reserve parachute. If undesirable behavior occurs with Multi-Instance - e.g., a certain functionality does not run as it should - switch back to Render Instance. "
https://help.maxon.net/c4d/2026/en-us/Default.htm#html/OMOGRAPH_CLONER-ID_OBJECTPROPERTIES.html#multi
Cheer